Abstract
Purpose: The purpose of this review is to describe computational models that have been developed for studying kidney function and howthese models may be adapted to study the eyes.
Methods: We derive equations for modeling solute andwater transport across epithelial cell membranes in the kidney. These equations describe mass conservation, as well membrane transport via cotransporters, exchangers, and primary active transport.
Results: Wedescribe howcomputational models of renal transport have been applied to investigate kidney function in physiological and pathophysiological conditions.
Conclusion: The computational models herein described for the kidney may be adapted to study ocular functions and dysfunction.
Reference51 articles.
1. Eaton DC, Pooler J, Vander AJ. Vander’s renal physiology. en. 7th. OCLC: 340936292. New York: McGraw-Hill Medical, 2009; ISBN: 978-0-07-161304-0. Available from: http://www.accessmedicine.com/resourceTOC.aspx?resourceID=57, visited on 11/13/2021.
2. Layton AT, Edwards A. Mathematical Modeling in Renal Physiology. eng. 1st ed. 2014. Lecture Notes on Mathematical Modelling in the Life Sciences. Berlin, Heidelberg: Springer Berlin Heidelberg, 2014. ISBN: 978-3-642-27367-4. https://doi.org/10.1007/978-3-642-27367-4.
3. Weinstein AM. A kinetically defined Na+/H+ antiporter within a mathematical model of the rat proximal tubule. Journal of General Physiology, May 1995;105(5): 617–641. https://doi.org/10.1085/jgp.105.5.617.
4. Layton AT, Vallon V, Edwards A. A computational model for simulating solute transport and oxygen consumption along the nephrons. eng. American journal of physiology. Renal physiology, 2016;311(6): https://doi.org/10.1152/ajprenal.00293.2016.
5. Okada Y. Ion channels and transporters involved in cell volume regulation and sensor mechanisms. Cell biochemistry and biophysics, 2004;41(2): 233–258.