Affiliation:
1. Industrial University of Ho Chi Minh City
Abstract
Erythrina fusca Lour. is a medicinal plant traditionally used in
herbal medicine; however, there are no records of toxicity associated with
the ethanol extract of E. fusca fruit (EtEF). The objective of this study
was to assess the safety of EtEF through toxicity testing. Four groups of
Swiss albino mice were employed, including a control group and three groups
administered EtEF at doses of 1000, 3000, and 5000 mg/kg (single dose) and
100, 300, and 500 mg/kg (administered repeatedly for 90 days). Various
parameters, including body weight, food and water consumption,
hematological and biochemical parameters, relative organ weight, urine
composition, and histopathology, were evaluated. No significant differences
were observed in the tested groups compared to the control group, and there
was no evidence of morphological or histopathological damage in the organs
of mice treated with EtEF. This study affirms the safety of EtEF and
establishes a foundation for further investigations into its utilization in
traditional medicine.
Reference46 articles.
1. Adedapo AA, Abatan MO, Olorunsogo OO (2004) Toxic effects of some plants in the genus Euphorbia on haematological and biochemical parameters of rats. Vet Arh 74(1):53-62.
2. Al-Afifi NA, Alabsi AM, Bakri MM, Ramanath A (2018) Acute and subacute oral toxicity of Dracaena cinnabariresin methanol extract in rats. BMC Complementary Altern Med 18(1):50.
3. Al-Awthan YS, Zarga MA, Abdalla S (2010) Flavonoids content of Dracaena cinnabari resin and effects of the aqueous extract on isolated smooth muscle preparations, perfused heart, blood pressure and diuresis in the rat. Jordan J Pharm Sci 3(1):8-16.
4. Anthanont P, Jensen MD (2016) Does basal metabolic rate predict weight gain? Am J Clin Nutr 104(4):959-963.
5. Effect of imidacloprid on hepatotoxicity and nephrotoxicity in male albino mice;Arfat;Toxicol Rep,2014