Bacteriophage Endolysins and their Applications-Reference-Cited by-同舟云学术

Bacteriophage Endolysins and their Applications

Published:2016-06 Issue:2 Volume:99 Page:183-199
ISSN:0036-8504
Container-title:Science Progress
language:en
Short-container-title:Science Progress

Author:

Ajuebor Jude¹,McAuliffe Olivia²,O'Mahony Jim³,Ross R. Paul⁴,Hill Colin⁵,Coffey Aidan⁶

Affiliation:

1. Cork Institute of Technology (CIT).

2. Teagasc Food Research Centre, Moorepark, County Cork, Ireland.

3. Cork Institute of Technology (CIT) at the Department of Biological Sciences.

4. Dean of the College of Science Engineering and Food Science at University College Cork.

5. University College Cork and a Principal Investigator in the Alimentary Pharmabiotic Centre.

6. Cork Institute of Technology at the Department of Biological Sciences and Head of the BioExplore Research Centre.

Abstract

Endolysins (lysins) are bacteriophage-encoded enzymes that have evolved to degrade specific bonds within the bacterial cell wall. These enzymes represent a novel class of antibacterial agents against infectious pathogens, especially in light of multidrug-resistant bacteria, which have made antibiotic therapy increasingly redundant. Lysins have been used successfully to eliminate/control bacterial pathogens in various anatomical locations in mouse and other animal models. Engineering tactics have also been successfully applied to improve lysin function. This review discusses the structure and function of lysins. It highlights protein-engineering tactics utilised to improve lysin activity. It also reviews the applications of lysins towards food biopreservation, therapeutics, bioifilm elimination and diagnostics.

Publisher

SAGE Publications

Subject

Multidisciplinary

Link

http://journals.sagepub.com/doi/pdf/10.3184/003685016X14627913637705

Reference103 articles.

1. A historical overview of bacteriophage therapy as an alternative to antibiotics for the treatment of bacterial pathogens

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4. The N-Terminal Region of the Oenococcus oeni Bacteriophage fOg44 Lysin Behaves as a Bona Fide Signal Peptide in Escherichia coli and as a cis -Inhibitory Element, Preventing Lytic Activity on Oenococcal Cells

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