Synthesis of 1-Substituted Indole-3-Carboxaldehyde related to Acyclic Nucleosides and their Condensed Pyrenyl Derivatives-Reference-Cited by-同舟云学术

Synthesis of 1-Substituted Indole-3-Carboxaldehyde related to Acyclic Nucleosides and their Condensed Pyrenyl Derivatives

Published:2001-01 Issue:1 Volume:2001 Page:9-9
ISSN:1747-5198
Container-title:Journal of Chemical Research
language:en
Short-container-title:Journal of Chemical Research

Author:

Zahran Magdy A.¹,Afify Hanan M.¹,Pedersen Erik B.²,Nielsen Claus³

Affiliation:

1. Chemistry Department, Faculty of Science, Menoufia University, Shebin El-Koam, Egypt

2. Department of Chemistry, University of Southern Denmark, Odense University, DK-5230 Odense M, Denmark

3. Department of Virology, State Serum Institute, DK-2300 Copenhagen S, Denmark

Abstract

Indole-3-carboxaldehyde was N-alkylated to give the corresponding acyclic nucleosides 3a–h which were condensed with 1-pyrenamine and 1-acetylpyrene to give 5a,c,e–g and 7b–d,e,g, respectively. The Schiff's bases 5a and 5e with 2-hydroxyethyl and methylthiomethyl N-1 substituents were found moderately active against HIV-1.

Publisher

SAGE Publications

Subject

General Chemistry

Link

http://journals.sagepub.com/doi/pdf/10.3184/030823401103168244

Reference9 articles.

1. Synthesis and hypotensive activity of benzamidopiperidylethylindoles

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1. Synthesis of 1-Acetylpyrene via Friedel-Crafts Reaction Using Chloroaluminate Ionic Liquids as Dual Catalyst and Solvent;Advanced Materials Research;2012-01

2. Efficient microwave irradiation enhanced stereoselective synthesis and antitumor activity of indolylchalcones and their pyrazoline analogs;Journal of Chemical Sciences;2010-07

3. ChemInform Abstract: Synthesis of 1-Substituted Indole-3-carboxaldehyde Related to Acyclic Nucleosides and Their Condensed Pyrenyl Derivatives.;ChemInform;2010-05-24

4. Synthesis and cellular cytotoxicities of new N-substituted indole-3-carbaldehyde and their indolylchalcones;Journal of Chemical Sciences;2009-07