Synthesis of Substituted Isoxazolones and Isoxazoles from Cyanoenaminones-Reference-Cited by-同舟云学术

Synthesis of Substituted Isoxazolones and Isoxazoles from Cyanoenaminones

Published:2006-02 Issue:2 Volume:2006 Page:78-80
ISSN:1747-5198
Container-title:Journal of Chemical Research
language:en
Short-container-title:Journal of Chemical Research

Author:

Mahalanabis Kumar K.¹,Chowdhury S.K. Dutta²,Sarkar Mili³,Misra Manisha¹

Affiliation:

1. Department of Chemistry, Jadavpur University, Kolkata 700 032, India

2. Jogesh Chandra Chaudhuri College, Kolkata 700 033, India

3. Gurudas College, Kolkata 700 054, India

Abstract

α-Cyano-β-enaminones, obtained by regioselective acylation of β-aminocrotononitrile, are smoothly and regiospecifically converted into substituted 5-isoxazolones, which on alkaline hydrolysis afford 4-acyl-3-substituted-5-hydroxyisoxazoles in good to excellent yields.

Publisher

SAGE Publications

Subject

General Chemistry

Link

http://journals.sagepub.com/doi/pdf/10.3184/030823406776330864

Reference27 articles.

1. Excitatory Amino Acid Receptor Ligands: Resolution, Absolute Stereochemistry, and Enantiopharmacology of 2-Amino-3-(4-butyl-3-hydroxyisoxazol-5-yl)propionic Acid

2. Use of Iodoacetylene as a Dipolarphile in the Synthesis of 5-Iodoisoxazole Derivatives

3. New isoxazole derivatives designed as nicotinic acetylcholine receptor ligand candidates

4. Design, Synthesis, and Pharmacology of a Highly Subtype-Selective GluR1/2 Agonist, (RS)-2-Amino-3-(4-chloro-3-hydroxy-5-isoxazolyl)propionic Acid (Cl-HIBO)

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1. Synthesis of Substituted Isoxazolones and Isoxazoles from Cyanoenaminones.;ChemInform;2006-07-18