Affiliation:
1. Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Cairo University, Cairo 11562, Egypt
2. Organic Chemistry Department, Faculty of Pharmacy, Beni-Swief University, Beni-Swief, Egypt
Abstract
The reaction of 3-hydrazinocarbonylmethylquinoxalin-2(1H)-one with phthalic anhydride, certain aromatic aldehydes, isocyanates and phenyl isothiocyanate furnished corresponding imide, Schiff's, semi- and thiosemicabazide derivatives. Treatment of 3-[2-(phenylcarbamoyl)hydrazinocarbonylmethyl]quinoxalin-2(1H)-one with chloroacetic acid, sulfuric acid and sodium hydroxide yielded cyclised derivatives. Moreover, 3-[2-bromobenzylidenehydrazinocarbonyl-methyl]quinoxalin-2(1H)-one was cyclised to oxadiazolinyl derivative using acetic anhydride. Furthermore, 3-[5-sulfanylidene-4,5-dihydro-1,3,4-oxadiazol-2-yl)methyl]quinoxalin-2(1H)-one was employed as a precursor in the synthesis of some novel 2(1H)-quinoxalinones. Some of the newly prepared compounds were evaluated for in vitro antibacterial activity using ofloxacin as the reference standard.
Cited by
2 articles.
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