Ionic liquid-Accelerated N-Arylation of Benzoazoles with Diaryliodonium Salts, An Efficient Method for the Synthesis of N-aryl Azoles-Reference-Cited by-同舟云学术

Ionic liquid-Accelerated N-Arylation of Benzoazoles with Diaryliodonium Salts, An Efficient Method for the Synthesis of N-aryl Azoles

Published:2004-03 Issue:3 Volume:2004 Page:206-207
ISSN:1747-5198
Container-title:Journal of Chemical Research
language:en
Short-container-title:Journal of Chemical Research

Author:

Wang Feng-Yan¹,Chen Zhen-Chu¹²,Zheng Qin-Guo³

Affiliation:

1. Department of Chemistry, Zhejiang University (Xixi campus), Hangzhou 310 028, P.R. China

2. Ningbo Institute of Technology, Zhejiang University, Ningbo 315 104, P.R. China

3. Pharmaceutical Sciences Research Institute, Aston University, Aston Triangle, Birmingham B4 7ET, UK

Abstract

N-Arylation of benzoazoles with diaryliodonium salts can be performed in good yields in the room-temperature ionic liquid 1–butyl–3–methylimidazolium tetrafluoroborate ([bmim]BF4), which provides an efficient method for the synthesis of N-arylbenzoazoles. The ionic liquid can be recycled and reused.

Publisher

SAGE Publications

Subject

General Chemistry

Link

http://journals.sagepub.com/doi/pdf/10.3184/0308234041640690

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1. Design and synthesis of potent N1-substituted indole melatonin receptor agonistsSelected data for 15: 1H NMR (200 MHz, CDCl3) δ 0.87–0.92 (t, 3H, CH3CH2, J = 7.3) 1.58–1.63 (quintet, 2H, CH2CH2CO, J = 7.3), 2.06–2.10 (t, 2H, CH2CO, J = 7.3) 2.86–2.89 (t, 2H, ArCH2, J = 6.8), 3.53–3.58 (q, 2H, CH2NH, J = 6.5), 3.83 (s, 3H, CH3O) 4.01 (s, 3H, CH3ON), 5.48 (br s, 1H, NHCO), 6.88–7.30 (m, 4H, Harom); 13C NMR (50 MHz, CDCl3) δ 13.7, 19.1, 25.3, 38.8, 39.4, 55.9, 65.7, 100.8, 108.6, 109.4, 112.9, 121.8, 122.7, 124.3, 154.5, 172.9. Anal. (C16H22N2O3) C, H, N.

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