Ligand-free Suzuki–Miyaura reaction catalysed by Pd/C at room temperature

Abstract

Ligand-free Suzuki–Miyaura coupling reaction has been developed which utilises a commercially available 10% Pd/C (2.6 mol% Pd) in 2-propanol-H2O (1/1) and Na3PO4 at room temperature. The reaction is mild and generates excellent yields of the coupled products (90–100%). The catalyst is heterogeneous and ligand-free, and the product isolation is simple.