Affiliation:
1. Chemistry Department, Faculty of Science, Zagazig University, Zagazig, Egypt
Abstract
The treatment of 1-benzyl-, or 1-methyl-6-chlorouracil (1a,b) with nucleophilic primary amines followed by nitrosation, reduction, formylation and dehydro-cyclisation lead to xanthines 5 and 7. While, the treatment of uracil 8 with aromatic aldehydes 9a–f leads to the formation of dipyrimidinopyridines 10a–f, reaction with formalin and primary amines gives pyrimidopyrimidines 11a–d via double Michael reactions.
Cited by
12 articles.
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1. Easy preparation, characterization and reactions of new
8‐chloro‐7‐formyl‐4‐oxo‐2‐phenyl‐4
H
‐pyrimido[1,2‐
a
]pyrimidine‐3‐carbonitrile;Journal of Heterocyclic Chemistry;2021-02-19
2. Convenient Methodology for Some Heterocyclization Reactions with Thioxopyrimidine Derivatives;Russian Journal of Organic Chemistry;2020-11
3. Convenient One-Pot Four-Component Synthesis of 6,8-Disubstituted-5,6,7,8-tetrahydropyrimido[4,5-d]pyrimidin-4(3H)-ones via a Triple Mannich Reaction;Australian Journal of Chemistry;2019
4. Novel pyrimidine-pyridine hybrids: Synthesis, cyclooxygenase inhibition, anti-inflammatory activity and ulcerogenic liability;Bioorganic Chemistry;2018-04
5. One pot synthesis, antimicrobial and antioxidant activities of fused uracils: pyrimidodiazepines, lumazines, triazolouracil and xanthines;Chemistry Central Journal;2017-07-19