A Revised Synthesis of the Antitumour Antibiotic L-azatyrosine via 2-iodo-5-methoxypyridine-Reference-Cited by-同舟云学术

A Revised Synthesis of the Antitumour Antibiotic L-azatyrosine via 2-iodo-5-methoxypyridine

Published:2001-12 Issue:12 Volume:2001 Page:546-548
ISSN:1747-5198
Container-title:Journal of Chemical Research
language:en
Short-container-title:Journal of Chemical Research

Author:

Seton Alison W.¹,Stevens Malcolm F. G.¹,Westwell Andrew D.¹

Affiliation:

1. Cancer Research Laboratories, School of Pharmaceutical Sciences, University of Nottingham, University Park, Nottingham, NG7 2RD, UK.

Abstract

A revised synthesis of the antitumour antibiotic L-azatyrosine is reported, the main features of which are the unam-biguous synthesis of the previously misinterpreted 2-iodo-5-methoxypyridine and subsequent palladium-catalysed coupling with an iodoalanine-derived zinc reagent.

Publisher

SAGE Publications

Subject

General Chemistry

Link

http://journals.sagepub.com/doi/pdf/10.3184/030823401103168839

Reference17 articles.

1. l-Azatyrosine: a new lead in anticancer drug development

2. Azatyrosine: Mechanism of Action for Conversion of Transformed Phenotype to Normal

3. A concise synthesis of either enantiomer of azatyrosine

4. A Practical Synthesis of l-Azatyrosine

5. Diastereoselective Synthesis of the Antibiotic L-Azatyrosine

Cited by 9 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Crystal structure of 6-ethoxypyridin-1-ium-2-olate;Acta Crystallographica Section E Structure Reports Online;2014-10-04

2. Effects of a Hydroxyl Substituent on the Reactivity of the 2,4,6-Tridehydropyridinium Cation, an Aromatic σ,σ,σ-Triradical;Chemistry - A European Journal;2011-12-16

3. Selective Catalytic Hydrogenation of Nitro Groups in the Presence of Activated Heteroaryl Halides;The Journal of Organic Chemistry;2011-11-08

4. ChemInform Abstract: A Revised Synthesis of the Antitumor Antibiotic L-Azatyrosine via 2-Iodo-5-methoxypyridine.;ChemInform;2010-05-21

5. Functionalized Organozinc Compounds;PATAI'S Chemistry of Functional Groups;2009-12-15