Regioselective Synthesis of 4′-amino-1′H-spiro[cyclohexane-1,2′-(pyrimido [1,2-a]benzimidazole)]-3′-carbonitrile in Aqueous Medium-Reference-Cited by-同舟云学术

Regioselective Synthesis of 4′-amino-1′H-spiro[cyclohexane-1,2′-(pyrimido [1,2-a]benzimidazole)]-3′-carbonitrile in Aqueous Medium

Published:2007-03 Issue:3 Volume:2007 Page:155-159
ISSN:1747-5198
Container-title:Journal of Chemical Research
language:en
Short-container-title:Journal of Chemical Research

Author:

Dandia Anshu¹,Sarawgi Pritima¹,Bingham Ann L.²,Drake John E.³,Hursthouse Michael B.²,Light Mark E.²,Ratnani Raju⁴

Affiliation:

1. Department of Chemistry, University of Rajasthan, Jaipur 302 004, India

2. Department of Chemistry, University of Southampton, Highfield, Southampton SO17 1BJ, UK

3. Department of Chemistry and Biochemistry, University of Windsor, Windsor, N9B 3P4 Ontario, Canada

4. Department of Pure & Applied Chemistry, M.D.S. University, Ajmer 305 009, India

Abstract

A simple, mild and environment-friendly procedure for synthesis of 4′-amino-1′H-spiro[cyclohexane-1,2′-(pyrimido[1,2-a]benzimidazole)]-3′-carbonitrile is developed using microwave irradiation in water. The product is obtained in short time, in excellent yield, and in a good state of purity. The reaction pathway and the influence of reaction conditions on regiochemistry are also investigated. The regioselectivity in this process is confirmed chemically and by single-crystal X-ray molecular structure determination.

Publisher

SAGE Publications

Subject

General Chemistry

Link

http://journals.sagepub.com/doi/pdf/10.3184/030823407X198582

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