A Simple Synthesis of 1,1,2-tris-(Hydroxymethyl)-Cyclopropane and Its Dihalo Derivatives-Reference-Cited by-同舟云学术

A Simple Synthesis of 1,1,2-tris-(Hydroxymethyl)-Cyclopropane and Its Dihalo Derivatives

Published:2002-09 Issue:9 Volume:2002 Page:459-460
ISSN:1747-5198
Container-title:Journal of Chemical Research
language:en
Short-container-title:Journal of Chemical Research

Author:

Finta Zoltán¹,Hell Zoltán¹,Cwik Agnieszka¹,Tőke László¹

Affiliation:

1. Department of Organic Chemical Technology, Budapest University of Technology and Economics, H-1521 Budapest, Hungary

Abstract

The phase transfer catalytic cyclopropanation of the malonic ester of allylic alcohol or its 3,3-dibromo and 3,3-dichloro derivatives yields bicyclic cyclopropane carboxylic acid lactones; reduction of these lactones with LiAlH4 in boiling THF yields the appropriate 1,1,2-tris-(hydroxymethyl)cyclopropanes in satisfactory yield.

Publisher

SAGE Publications

Subject

General Chemistry

Link

http://journals.sagepub.com/doi/pdf/10.3184/030823402103172653

Reference9 articles.

1. Synthesis of cyclopropyl carbocyclic nucleosides

2. Preparation of novel difluorocyclopropane nucleosides

3. Synthesis of difluorocyclopropyl carbocyclic homo-nucleosides

4. Single electron transfer induced elemental steps in the transformation of iodomalonic esters and related CH-acids under solid-liquid PTC conditions. Preparation of electrophilic cyclopropanes

5. Mg-Al 3:1 hydrotalcite catalyst in the synthesis of cyclopropane carboxylic acid derivatives

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1. Enantiomerically Pure Synthesis of β-Substituted γ-Butyrolactones: A Key Intermediate to Concise Synthesis of Pregabalin;The Journal of Organic Chemistry;2007-08-23

2. A Simple Synthesis of 1,1,2-Tris-(hydroxymethyl)cyclopropane and Its Dihalo Derivatives.;ChemInform;2003-02-04