Difluorinated carbaacyclonucleosides: Synthesis and evaluation of antiviral activity-Reference-Cited by-同舟云学术

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Difluorinated carbaacyclonucleosides: Synthesis and evaluation of antiviral activity

Published:2001-08 Issue:8 Volume:2001 Page:311-312
ISSN:1747-5198
Container-title:Journal of Chemical Research
language:en
Short-container-title:Journal of Chemical Research

Author:

Lewis Maureen¹,De Clercq Erik²

Affiliation:

1. University Chemical Laboratory, Trinity College, Dublin 2, Ireland

2. Rega Institute for Medical Research, Katholieke Universiteit Leuven, B-3000 Leuven, Belgium

Abstract

The synthesis of 4-benzoyloxy-5,5-difluoropentan-1-ol from ethyl difluoroacetate is described; its condensation with pyrimidine bases gave carbaacyclonucleosides. which were evaluated, and found inactive, in a large variety of antiviral assays.

Publisher

SAGE Publications

Subject

General Chemistry

Link

http://journals.sagepub.com/doi/pdf/10.3184/030823401103170061

Reference22 articles.

1. Synthesis and Biological Activity of 2',2'-Difluorodeoxycytidine (Gemcitabine)

2. A remarkably simple route to versatile difluoromethylated molecules

3. Lanthanoids in organic synthesis. 5. Selective reductions of ketones in the presence of aldehydes

4. Organic reactions in aqueous media - with a focus on carbon-carbon bond formation

5. Selective tin and zinc mediated allylations of carbonyl compounds in aqueous media

Cited by 1 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. ChemInform Abstract: Difluorinated Carbaacyclonucleosides: Synthesis and Evaluation of Antiviral Activity.;ChemInform;2010-05-23

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