Synthesis of Carnitine Benzyl Esters as Prodrugs-Reference-Cited by-同舟云学术

Synthesis of Carnitine Benzyl Esters as Prodrugs

Published:2008-06 Issue:6 Volume:2008 Page:327-330
ISSN:1747-5198
Container-title:Journal of Chemical Research
language:en
Short-container-title:Journal of Chemical Research

Author:

Gong Xiao-wei¹,Li Jin-pei²,Wu Ji-feng³,Xun Li¹,Zhai Hai-min⁴,Feng Bo⁴,Xu Wen-fang¹,Tang Wei¹⁵

Affiliation:

1. College of Pharmacy, Shandong University, Ji'nan 250012, P.R. China

2. Liaocheng People's Hospital, 252000, P.R. China

3. Ji'nan Public Security, Shandong, 250000, P.R. China

4. Qidu Pharmaceutical Co. LTD, Zibo, 255400, P.R. China

5. Hepato-Biliary-Pancreatic Surgery Division, Department of Surgery, Graduate School of Medicine, the University of Tokyo, Tokyo 113-8655, Japan

Abstract

The introduction of C-2 acyl groups and a benzyl ester onto L-carnitine generated a series of carnitine benzyl esters as prodrug with improved liposolubility, stability and bioavailability.

Publisher

SAGE Publications

Subject

General Chemistry

Link

http://journals.sagepub.com/doi/pdf/10.3184/030823408X324689

Reference15 articles.

1. FritzI.B., Current Concepts in Carnitine Research, ed. CarterA.L. CRC Press, Boca Raton, FL, 1992, pp. 107.

2. Polycarnitine?a new biomaterial

3. Carnitine: transport and physiological functions in the brain

4. Characterization of organic cation/carnitine transporter family in human sperm

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