Sodium dithionite-promoted synthesis of 2-arylbenzothiazoles by reaction of 2,2'-disulfanediyldianiline with aldehydes in water-Reference-Cited by-同舟云学术

Sodium dithionite-promoted synthesis of 2-arylbenzothiazoles by reaction of 2,2'-disulfanediyldianiline with aldehydes in water

Published:2009-11 Issue:11 Volume:2009 Page:682-685
ISSN:1747-5198
Container-title:Journal of Chemical Research
language:en
Short-container-title:Journal of Chemical Research

Author:

Yang Xiaoliang¹,Xu Yali¹,Chen Jiuxi¹,Ding Jinchang¹²,Wu Huayue¹,Su Weike¹³

Affiliation:

1. College of Chemistry and Materials Science, Wenzhou University, Wenzhou 325027, P.R. China

2. Wenzhou Vocational and Technical College, Wenzhou, 325035, P.R. China

3. College of Pharmaceutical Sciences, Zhejiang University of Technology, Zhejiang Key Laboratory of Pharmaceutical Engineering, Hangzhou, 310014, P.R. China

Abstract

Sodium dithionite-promoted synthesis of 2-arylbenzothiazoles by reaction of 2,2'-disulfanediyldianiline with aldehydes in the presence of sodium dodecyl sulfate in water has been developed. Possible reaction pathways are discussed and the effects of different promoter on the reaction are investigated. The important features of this methodology are simple work-up, environmentally benign, high yields, metal-free, and inexpensive reagents.

Publisher

SAGE Publications

Subject

General Chemistry

Link

http://journals.sagepub.com/doi/pdf/10.3184/030823409X12560401198996

Reference42 articles.

1. The Development of the Antitumour Benzothiazole Prodrug, Phortress, as a Clinical Candidate

2. Antitumor Benzothiazoles. 16. Synthesis and Pharmaceutical Properties of Antitumor 2-(4-Aminophenyl)benzothiazole Amino Acid Prodrugs

3. Room temperature ionic liquid promoted regioselective synthesis of 2-aryl benzimidazoles, benzoxazoles and benzthiazoles under ambient conditions

4. An Efficient Synthesis of Benzothiazoles by Direct Condensation of Carboxylic Acids with 2-Aminothiophenol under Microwave Irradiation

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