The Reaction of Alkyl Isocyanides and Benzylidene Meldrum's Acid Derivatives in the presence of Water: A One-Pot synthesis of 4-(Alkylamino)-3-Aryl-4-Oxobutanoic Acids-Reference-Cited by-同舟云学术

The Reaction of Alkyl Isocyanides and Benzylidene Meldrum's Acid Derivatives in the presence of Water: A One-Pot synthesis of 4-(Alkylamino)-3-Aryl-4-Oxobutanoic Acids

Published:2002-09 Issue:9 Volume:2002 Page:433-435
ISSN:1747-5198
Container-title:Journal of Chemical Research
language:en
Short-container-title:Journal of Chemical Research

Author:

Shaabani Ahmad¹²,Teimouri Mohammad Bagher¹

Affiliation:

1. Department of Chemistry, Shahid Beheshti University, PO Box 19396-4716, Tehran, Iran

2. Medicinal and Aromatic Plants and Drug Research Institute, Shahid Beheshti University, PO Box 19396-4716, Tehran, Iran

Abstract

The reaction between alkyl isocyanides and substituted-benzylidene Meldrum's acid derivatives in the presence of water produces 4-(alkylamino)-3-aryl-4-oxobutanoic acids in good yields.

Publisher

SAGE Publications

Subject

General Chemistry

Link

http://journals.sagepub.com/doi/pdf/10.3184/030823402103172761

Reference13 articles.

1. LIV.—A β-lactonic acid from acetone and malonic acid

2. New and efficient synthesis of dialkyl 2-[1- p -nitrophenyl-2-(alkylamino)-2-oxoethyl]malonates

3. Studies on antirheumatic agents. 3-Benzoylpropionic acid derivatives.

4. Studies on hypolipidemic agents. II. 3-(4-Phenoxybenzoyl)propionic acid derivatives.

5. Preparation and Antirheumatic Activity of Optically Active 2-Acetylthiomethyl-4-(4-methylphenyl)-4 oxobutanoic Acid (KE-298).

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