Friedel–Crafts allylation of 2-(benzyloxy)-3,4,5-trimethoxytoluene Catalysed by a Metal Trifluoromethanesulfonic Salt: Synthesis of Coenzyme Q10-Reference-Cited by-同舟云学术

Friedel–Crafts allylation of 2-(benzyloxy)-3,4,5-trimethoxytoluene Catalysed by a Metal Trifluoromethanesulfonic Salt: Synthesis of Coenzyme Q10

Published:2007-12 Issue:12 Volume:2007 Page:686-688
ISSN:1747-5198
Container-title:Journal of Chemical Research
language:en
Short-container-title:Journal of Chemical Research

Author:

Zheng Yun-Feng¹,Lin Jing-Du¹,Li Cheng-Ping²,Li Jing-Hua¹

Affiliation:

1. College of Pharmaceutical Sciences, Zhejiang University of Technology, 310032, P. R. China

2. College of Biology and Environmental Engineering, Zhejiang Shuren University, 310015, P. R. China

Abstract

In the presence of a catalytic amount of scandium triflate, 2-benzyloxy-3,4,5-trimethoxytoluene reacted with allylic derivatives 4, giving the key intermediate 3 (R = benzyl) which was used for preparing coenzyme Q10, in moderate to high yields.

Publisher

SAGE Publications

Subject

General Chemistry

Link

http://journals.sagepub.com/doi/pdf/10.3184/030823407X270338

Reference31 articles.

1. Isolation of a quinone from beef heart mitochondria

2. Identification

3. An expeditious route to CoQn, vitamins K1 and K2, and related allylated para-quinones utilizing Ni(0) catalysis

4. Synthetic Studies on Coenzyme Q10. Part 2

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