Synthesis of 1-(6-Methyl-2,4-Dioxo-1,2,3,4-Tetrahydro-3-Pyrimidinyl)Acetyl-4-Alkyl(Aryl)Thiosemicarbazides and their Heterocyclisation to 1,2,4-Triazoles and 1,3,4-Thiadiazoles-Reference-Cited by-同舟云学术

Synthesis of 1-(6-Methyl-2,4-Dioxo-1,2,3,4-Tetrahydro-3-Pyrimidinyl)Acetyl-4-Alkyl(Aryl)Thiosemicarbazides and their Heterocyclisation to 1,2,4-Triazoles and 1,3,4-Thiadiazoles

Published:2002-04 Issue:4 Volume:2002 Page:170-172
ISSN:1747-5198
Container-title:Journal of Chemical Research
language:en
Short-container-title:Journal of Chemical Research

Author:

Smicius Romualdas¹,Jakubkiene Virginija¹,Burbuliene Milda M.¹,Mikalainyte Aiste¹,Vainilavicius Povilas¹

Affiliation:

1. Department of Organic Chemistry, Faculty of Chemistry, Vilnius University, Naugarduko 24, LT-2006 Vilnius, Lithuania

Abstract

5-(6-Methyl-2,4-dioxo-1,2,3,4-tetrahydro-3-pyrimidinyl)methyl-1,3,4-oxadiazole-2-thione reacts with amines to give 1-(6-methyl-2,4-dioxo-1,2,3,4-tetrahydro-3-pyrimidinyl)acetyl-4-alkyl(aryl)thiosemicarbazides, which on treatment with base or acid undergo cyclisation to 4-alkyl-1,2,4-triazole-2-thiones or 4-amino-1,3,4-thiadiazoles, respectively.

Publisher

SAGE Publications

Subject

General Chemistry

Link

http://journals.sagepub.com/doi/pdf/10.3184/030823402103171555

Reference6 articles.

1. Improved syntheses of 5-substituted-4-amino-3-mercapto-(4H)-1,2,4-triazoles

2. Synthesis of 5-(6-Methyl-2,4-dioxo-1,2,3,4-tetrahydro-3-pyrimidinyl)-methyl-4-amino-1,2,4-triazole-3-thione and its Reactions with Polyfunctional Electrophiles

3. 2,4-Dihydro-3H-1,2,4-triazole-3-thiones as potential antidepressant agents

Cited by 12 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Equilibrium, DNA Cleavage and Antimicrobial Studies of Cu(II) and Zn(II) Complexes with Novel 1-Propionyl-4-methyl-3-thiosemicarbazide;Asian Journal of Chemistry;2019-11-18

2. Desulfurization processes of thiosemicarbazonecopper(ii) derivatives in acidic and basic aqueous media;New Journal of Chemistry;2013

3. Synthesis of new pyrimidinylthio-substituted 1,3,4-oxa(thia)diazoles and 1,2,4-triazoles;Journal of Sulfur Chemistry;2012-08

4. Heterocyclization of acylthiosemicarbazides;Journal of Heterocyclic Chemistry;2011-10-21

5. ChemInform Abstract: Synthesis of 1-(6-Methyl-2,4-dioxo-1,2,3,4-tetrahydro-3-pyrimidinyl)acetyl-4-alkyl (aryl)thiosemicarbazides and Their Heterocyclization to 1,2,4-Triazoles and 1,3,4-Thiadiazoles.;ChemInform;2010-05-19