Enzyme Catalysed Kinetic Resolution of Racemic Methyl 3-acethylbicyclo [2.2.1] hept-5-ene-2-carboxylate using pig's liver esterase†-Reference-Cited by-同舟云学术

Enzyme Catalysed Kinetic Resolution of Racemic Methyl 3-acethylbicyclo [2.2.1] hept-5-ene-2-carboxylate using pig's liver esterase†

Published:2002-08 Issue:8 Volume:2002 Page:386-387
ISSN:1747-5198
Container-title:Journal of Chemical Research
language:en
Short-container-title:Journal of Chemical Research

Author:

Mamaghani Manouchehr¹,Alizadehnia Alireza¹

Affiliation:

1. Chemistry Department, Faculty of Sciences, Guilan University, PO Box 1914, Rasht, Iran

Abstract

Racemic methyl 3- endo-acetylbicyclo[2.2.1]hept-5-ene-2- exo-carboxylate and methyl 3- exo-acetylbicyclo[2.2.1]hept-5-ene-2- endo-carboxylate were prepared (as a 1:1 mixture in 98% yield) from (E)-methyl 4- oxo-2-pentenoate, using Diels–Alder methodology. The mixture was separated chromatographically and resolved into the enantiomers by pig liver esterase (PLE) with low to high ee's (98%).

Publisher

SAGE Publications

Subject

General Chemistry

Link

http://journals.sagepub.com/doi/pdf/10.3184/030823402103172400

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