Coordination and biological behaviour of 2-(p-toluidino)-N'-(3-oxo-1,3-diphenylpropylidene) acetohydrazide and its metal complexes

Abstract

A series of Ni(II), Co(II), Cu(II), Mn(II), Zn(II), Zr(IV), Fe(III), Ru(III), La(III), Hf(IV) and U(VI) complexes of 2-( p-toluidino)-N'-(3-oxo-1,3-diphenylpropylidene) acetohydrazide (H2L) have been synthesised and characterised by elemental and thermal analyses (DTA, TG), molar conductances, magnetic moments, IR, 1H NMR, UV-Vis spectra and ESR measurements. The ESR spectra of solid complexes [(L)(HL)Cu2(OAc)], [Cu(HL)(H2L)(NO3)] and [CuCl (HL)(H2L)].H2O at room temperature show axial symmetry with covalent bond character, and complex [FeCl2(HL)(H2O)] has gav = 4.38, indicating a high spin (5/2) iron(III) complex. However, complexes [(HL)Mn2Cl3(H2O)4] and [RuCl2(HL)(H2O)].H2O have isotropic spectra consistent with octahedral structure. The antifungal and antibacterial activities of the ligand and its complexes were investigated.