Affiliation:
1. Centro de Química, IVIC, Aptdo. 21827, Caracas-1020A, Venezuela
Abstract
The commercially available 3-hydroxy-4-methoxy-benzaldehyde 3 was subjected to hydrogenation and protection to give the methoxy methyl ether of 2-methoxy-5-methylphenol. This was converted to 1,8-dimethyl-5-methoxytetralin-6-ol by alkylation with 5-bromopent-1-ene, cyclisation and deprotection.