Facile synthesis of substituted arylthioureas in the presence of sodium hydride-Reference-Cited by-同舟云学术

Facile synthesis of substituted arylthioureas in the presence of sodium hydride

Published:2017-05 Issue:5 Volume:41 Page:301-303
ISSN:1747-5198
Container-title:Journal of Chemical Research
language:en
Short-container-title:Journal of Chemical Research

Author:

Cao Qiang¹,Liu Fang¹,Wang Min¹,Xu Wan¹,Zeng Meng-Tian¹,Liu Min¹,Li Yue-Sheng²,Dong Zhi-Bing¹³

Affiliation:

1. School of Chemistry and Environmental Engineering, Wuhan Institute of Technology, Wuhan 430074, P.R. China

2. Nonpower Nuclear Technology Collaborative Innovation Center, Hubei University of Science and Technology, Xianning 437100, P. R. China

3. Key Laboratory of Green Chemical Process, Ministry of Education, Wuhan Institute of Technology, Wuhan 430074, P.R. China

Abstract

A series of 11 1,1-dimethyl-3-aryl-thioureas were synthesised in good yields (70–92%) by reacting arylamines with S-aryl- N,N-dimethylthiocarbamate in DMSO in the presence of NaH at 90 °C. It is noteworthy that this method can also be used for arylamines containing a halogen atom at the ortho position.

Publisher

SAGE Publications

Subject

General Chemistry

Link

http://journals.sagepub.com/doi/pdf/10.3184/174751917X14931424175476

Reference18 articles.

1. Signal transduction by receptors with tyrosine kinase activity

2. Thienopyrimidine Ureas as Novel and Potent Multitargeted Receptor Tyrosine Kinase Inhibitors

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4. Design, synthesis and antitumor evaluation of a new series of N-substituted-thiourea derivatives

5. Synthesis and structure–activity relationships of N-benzyl-N-(X-2-hydroxybenzyl)-N′-phenylureas and thioureas as antitumor agents

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