A Cross-Coupling Synthesis of Functionalised Biaryls Using Knochel-Type Organozinc Reagents and a Pyridine Enhanced Palladium Catalyst-Reference-Cited by-同舟云学术

A Cross-Coupling Synthesis of Functionalised Biaryls Using Knochel-Type Organozinc Reagents and a Pyridine Enhanced Palladium Catalyst

Published:2016-06 Issue:6 Volume:40 Page:382-384
ISSN:1747-5198
Container-title:Journal of Chemical Research
language:en
Short-container-title:Journal of Chemical Research

Author:

Wang Min¹,Liu Fang¹,Zeng Meng-Tian¹,Xu Wan¹,Liu Min¹,Dong Zhi-Bing¹²

Affiliation:

1. School of Chemistry and Environmental Engineering, Wuhan Institute of Technology, Wuhan 430074, P.R. China

2. Key Laboratory of Green Chemical Process, Ministry of Education, Wuhan Institute of Technology, Wuhan 430074, P.R. China

Abstract

A variety of functionalised biaryls were synthesised on the 20–30 mmol scale by using Knochel type organozinc reagents (organozinc reagents prepared from aryl halides, Zn powder and LiCl) catalysed by PEPPSI (a pyridine enhanced palladium catalyst). The protocol enabled the Negishi reactions to proceed in a smooth, rapid and mild way to give the corresponding products in excellent yields (80 ~ 96%). Sensitive functional groups, such as CN and COOEt groups, were tolerated in the coupling reaction.

Publisher

SAGE Publications

Subject

General Chemistry

Link

http://journals.sagepub.com/doi/pdf/10.3184/174751916X14636735575269

Reference18 articles.

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4. Pd-Catalyzed Aryl Amination Mediated by Well Defined, N-Heterocyclic Carbene (NHC)–Pd Precatalysts, PEPPSI

5. Palladium-catalyzed cross-coupling reaction of homoallylic or homopropargylic organozincs with alkenyl halides as a new selective route to 1,5-dienes and 1,5-enynes

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1. Scaled-up Negishi-Coupling of Aryl Halides Bearing Unprotected Amides with Knochel-Type Organozinc Reagents;Journal of Chemical Research;2017-10

2. Synthetics Methods for the Preparation of Biaryls;Revista Virtual de Química;2017

3. ChemInform Abstract: A Cross-Coupling Synthesis of Functionalized Biaryls Using Knochel-Type Organozinc Reagents and a Pyridine Enhanced Palladium Catalyst.;ChemInform;2016-10