Convenient Two-step One-pot Synthesis of Benzimidazoles Using 2-nitroanilines and Thiourea Dioxide-Reference-Cited by-同舟云学术

Convenient Two-step One-pot Synthesis of Benzimidazoles Using 2-nitroanilines and Thiourea Dioxide

Published:2014-02 Issue:2 Volume:38 Page:118-120
ISSN:1747-5198
Container-title:Journal of Chemical Research
language:en
Short-container-title:Journal of Chemical Research

Author:

Pu Shuai¹,Liang Qiuxiang¹,Luo Xi¹,Luo Juan¹

Affiliation:

1. College of Chemistry, Sichuan University, 29 Wangjiang Road, Chengdu 610064, P.R. China

Abstract

A new convenient method for the conversion of 2-nitroanilines into benzimidazoles by two-step one-pot procedure is reported. The procedure involves the reduction of nitro group followed by the intramolecular cyclisation of the corresponding o-phenylenediamines utilising thiourea dioxide and sodium hydroxide at 70 °C in mixed solvents of H2O and EtOH (v/v, 3/1). The yields are good to excellent and the workup is simple.

Publisher

SAGE Publications

Subject

General Chemistry

Link

http://journals.sagepub.com/doi/pdf/10.3184/174751914X13896361235211

Reference19 articles.

1. Antitumor Benzothiazoles. 26. 2-(3,4-Dimethoxyphenyl)-5-fluorobenzothiazole (GW 610, NSC 721648), a Simple Fluorinated 2-Arylbenzothiazole, Shows Potent and Selective Inhibitory Activity against Lung, Colon, and Breast Cancer Cell Lines

2. Masked Imidazolyl−Dipyrromethanes in the Synthesis of Imidazole-Substituted Porphyrins

3. Synthesis and Biological Activity of Novel Nonnucleoside Inhibitors of HIV-1 Reverse Transcriptase. 2-Aryl-Substituted Benzimidazoles

4. The Combinatorial Synthesis of Bicyclic Privileged Structures or Privileged Substructures

5. Highly Potent, Water Soluble Benzimidazole Antagonist for Activated α4β1 Integrin

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