Exploiting a Step in Diterpenoid Biosynthesis by the Fungus Fusarium Fujikuroi

Abstract

The scope of the microbiological transformation of ent-kaurenoid diterpenes by the fungus Fusarium (Gibberella) fujikuroi which utilise the ent-kaurene and ent-kauren-19-oic acid oxidases and the ring contraction of ring B to gibberellin is reviewed. Constraints arising from the presence of 3α, 15α and 18-hydroxyl groups are noted. The development of a group of potential plant growth regulators which inhibit the ring contraction step in gibberellin biosynthesis is described.