Effect of Microwave Irradiation on the Synthesis of 1,2,4-Triazol-3-One Derivatives and their Antimicrobial Activities-Reference-Cited by-同舟云学术

Effect of Microwave Irradiation on the Synthesis of 1,2,4-Triazol-3-One Derivatives and their Antimicrobial Activities

Published:2012-08 Issue:8 Volume:36 Page:484-488
ISSN:1747-5198
Container-title:Journal of Chemical Research
language:en
Short-container-title:Journal of Chemical Research

Author:

Kahveci Bahittin¹,Yilmaz Fatih²,Menteşe Emre²,Beriş Fatih Şaban³

Affiliation:

1. Nutrition and Dietetics, Faculty of Health Sciences, Karadeniz Technical University, Trabzon 61080, Turkey

2. Department of Chemistry, Art and Science Faculty, Recep Tayyip Erdoğan University, Rize 53100, Turkey

3. Department of Biology, Art and Science Faculty, Recep Tayyip Erdoğan University, Rize 53100, Turkey

Abstract

An easy efficient method for the synthesis of N-(3,5-dichlorophenyl)-5-alkyl/aryl-3H-1,2,4-triazol-3-one derivatives under microwave irradiation has been developed using the reaction of 3,5-dichloroaniline and ethoxycarbonylhydrazones. This reaction occurs more efficiently and faster than the conventional heating method. We obtained 5-mercapto-1,3,4-oxadiazol derivatives by this method. The newly synthesised compounds have been tested for their antimicrobial activity against Enterobacter cloaceae, Escherichia coli, Klebsiella pneumonie, Pseudomonas aeruginosa, Proteus vulgaris, Salmonella typhimurium, Yersinia pseudotuberculosis, Bacillus subtilis and Staphylococcus aereus.

Publisher

SAGE Publications

Subject

General Chemistry

Link

http://journals.sagepub.com/doi/pdf/10.3184/174751912X13400138806685

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