Practical and Scalable Synthesis of Isosorbide Derivatives Containing an Active Amine Group

Abstract

The synthesis of two derivatives of isosorbide containing an amine group, 6-amino-6-deoxy- O-3-methyl-isosorbide and 6-amino- O-3-benzoyl-6-deoxy-isosorbide, has been achieved. These compounds provide scope for the introduction of additional groups via their amino functions and thereby can provide access to novel isosorbide derivatives that can be screened for biological activity.