Metal Catalyst-Free Amination of 2-chloro-5-nitrobenzoic Acid in Superheated Water

Author:

Lan Cong1,Xia Zhi-Ning1,Li Zheng-Hua1,Liang Rong-Hui1

Affiliation:

1. College of Chemistry and Chemical Engineering, Chongqing University, Chongqing 400044, P. R. China

Abstract

A series of N-arylanthranilic acid derivatives were synthesised by amination of 2-chloro-5-nitrobenzoic acid with various arylamine in superheated water with potassium carbonate as base. Good yields were achieved within 2-3 h at 150-190 °C. The results indicated that this metal catalyst-free method is a simple, environmentally-friendly and efficient synthesis of N-phenylanthranilic acid derivatives. Furthermore, it will work with an alkylamine and phenol.

Publisher

SAGE Publications

Subject

General Chemistry

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