An Efficient One-Pot Synthesis of 3-Aryl-5-(Dialkoxymethyl)-1,2,4-Oxadiazoles under Solvent-Free Conditions-Reference-Cited by-同舟云学术

An Efficient One-Pot Synthesis of 3-Aryl-5-(Dialkoxymethyl)-1,2,4-Oxadiazoles under Solvent-Free Conditions

Published:2016-05 Issue:5 Volume:40 Page:314-317
ISSN:1747-5198
Container-title:Journal of Chemical Research
language:en
Short-container-title:Journal of Chemical Research

Author:

Adib Mehdi¹,Saeedi Sara¹,Soheilizad Mehdi¹,Bayanati Maryam¹,Tajbakhsh Mahmood²,Amanlou Massoud³

Affiliation:

1. School of Chemistry, College of Science, University of Tehran, P.O. Box 14155-6455, Tehran, Iran

2. Department of Organic Chemistry, Faculty of Chemistry, Mazandaran University, Babolsar, Iran

3. Pharmaceutical Sciences Research Center and Department of Medicinal Chemistry, Tehran University of Medical Sciences, Tehran, Iran

Abstract

An efficient and simple synthesis of 3-aryl-5-(dialkoxymethyl)-1,2,4-oxadiazoles is described. The in situ prepared amidoximes from the reaction between nitriles and hydroxylamine are condensed with alkyl 2,2-dialkoxyacetates under solvent-free conditions to produce the title compounds in excellent yields.

Publisher

SAGE Publications

Subject

General Chemistry

Link

http://journals.sagepub.com/doi/pdf/10.3184/174751916X14608135651135

Reference27 articles.

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3. ChemInform Abstract: An Efficient One-Pot Synthesis of 3-Aryl-5-(dialkoxymethyl)-1,2,4-oxadiazoles under Solvent-Free Conditions.;ChemInform;2016-09