Affiliation:
1. College of Chemistry and Environmental Science, Henan Normal University, Xinxiang 453007, P. R. China
Abstract
Paeonol is a major phenolic component isolated from Moutan Cortex, a traditional Chinese medicine. An efficient synthesis of paeonol derivatives linked to a 1,2,3-triazole moiety using a 1,3-dipolar Huisgen-cycloaddition reaction is described. The paeonol derivatives are regioselectively obtained in good yields under mild conditions using Cu(OAc)2·H2O/sodium ascorbate as a catalyst system, and t-BuOH/H2O (1:1, v/v) as a co-solvent.
Cited by
5 articles.
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1. Synthesis and Evaluation of Antibacterial Activity of 1,2,3-Triazole and Ether Derivatives of Paeonol;Journal of the Brazilian Chemical Society;2022
2. Design, synthesis, and antitumor activity of novel paeonol derivatives containing the 1,4-benzoxazinone and 1,2,3-triazole moieties;Journal of Chemical Research;2019-07
3. Design, synthesis, and antilung adenocarcinoma activity research of novel paeonol Schiff base derivatives containing a 1,2,3‐triazole moiety;Journal of the Chinese Chemical Society;2019-06-14
4. Design, Synthesis and Antifungal Activity of Novel Paeonol Derivatives Linked with 1,2,3-Triazole Moiety by the Click Reaction;Journal of Chemical Research;2015-04
5. ChemInform Abstract: Synthesis of Paeonol Derivatives Linked with 1,2,3-Triazole Moiety (III) by 1,3-Dipolar Huisgen-Cycloaddition Reaction.;ChemInform;2013-01-08