Design and Synthesis of (3,5-Disubstituted Isoxazole)-Linked [1,5]-Benzodiazepine Conjugates: Evaluation of their Antimicrobial and Anti-Tyrosinase Activities-Reference-Cited by-同舟云学术

Design and Synthesis of (3,5-Disubstituted Isoxazole)-Linked [1,5]-Benzodiazepine Conjugates: Evaluation of their Antimicrobial and Anti-Tyrosinase Activities

Published:2017-01 Issue:1 Volume:41 Page:12-17
ISSN:1747-5198
Container-title:Journal of Chemical Research
language:en
Short-container-title:Journal of Chemical Research

Author:

Abdallah Wejdane¹²,Daami-Remadi Mejda³,Znati Mansour²,Jannet Hichem Ben²,Gharbi Rafik¹

Affiliation:

1. Laboratory of Applied Chemistry and Environment, Faculty of Science of Monastir, University of Monastir, 5019 Monastir, Tunisia

2. Laboratory of Heterocyclic Chemistry, Natural Products and Reactivity (LR11SE39), Team: Medicinal Chemistry and Natural Products and Reactivity, Faculty of Science of Monastir, University of Monastir, 5019 Monastir, Tunisia

3. Integrated Horticultural Production in the Tunisian Centre East, The Regional Centre of Research on Horticulture and Organic Agriculture of Chott-Mariem, Sousse University, Chott-Mariem, 4042 Tunisia

Abstract

A series of novel 2-(3,5-disubstituted isoxazolyl)-1,5-benzodiazepines and 2,4-bis-(3,5-disubstituted isoxazolyl)-1,5-benzodiazepine derivatives have been designed and synthesised by employing an alkyne/nitrile oxide cycloaddition ‘click’ type chemistry protocol. The structures of the compounds were determined on the basis of 1H, 13C and 2D-NMR techniques and by HRMS analysis. These hybrid molecules exhibit moderate to significant antimicrobial and anti-tyrosinase activities.

Publisher

SAGE Publications

Subject

General Chemistry

Link

http://journals.sagepub.com/doi/pdf/10.3184/174751917X14815427219121

Reference21 articles.

1. Enhancing neurosteroid synthesis – Relationship to the pharmacology of translocator protein (18 kDa) (TSPO) ligands and benzodiazepines

2. Pyrrolo[2,1-c][1,4]benzodiazepine as a Scaffold for the Design and Synthesis of Anti- Tumour Drugs

3. Synthesis, DNA-binding abilities and anticancer activities of triazole-pyrrolo[2,1-c][1,4]benzodiazepines hybrid scaffolds

4. Synthesis of a C2-aryl-pyrrolo[2,1-c][1,4]benzodiazepine monomer enabling the convergent construction of symmetrical and non-symmetrical dimeric analogs

5. 1,5-Benzodiazepine derivatives as potential antimicrobial agents: design, synthesis, biological evaluation, and structure–activity relationships

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