Facile and Efficient Synthesis of Novel 1,2,3-Thiadiazole Derivatives using Microwave Irradiation

Author:

Zhai Zhi-Wen1,Yang Ming-Yan1,Sun Zhao-Hui1,Liu Xing-Hai1,Weng Jian-Quan1,Tan Cheng-Xia1

Affiliation:

1. College of Chemical Engineering, Zhejiang University of Technology, Hangzhou, 310014, P.R. China

Abstract

A series of novel urea derivatives containing the 1,2,3-thiadiazole moiety were synthesised using microwave-assisted condensation reactions of 4-methyl-1,2,3-thiadiazole-5-carbohydrazide with various substituted isocyanatobenzenes in acetonitrile. Their chemical structures were characterised by 1H NMR, MS and elemental analysis. This method provides several advantages such as high yields, facile work-up and is environmentally friendly.

Publisher

SAGE Publications

Subject

General Chemistry

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