The Trifluoromethylation of Iminium Salts by the Addition of Trifluoromethyltrimethylsilane

Author:

Liu Haidong12,Chen Bo1,Cai Jin3,Chen Junqing3,Ji Min12

Affiliation:

1. School of Biological Science and Medical Engineering, Southeast University, Si Pai Lou 2#, Nanjing City 210096, P.R. China

2. Suzhou Key Laboratory of Biomaterials and Technologies & Collaborative Innovation Center of Suzhou Nano Science and Technology, Suzhou, 215123, P.R. China

3. School of Chemistry and Chemical Engineering, Southeast University Si Pai Lou 2#, Nanjing City 210096, P.R. China

Abstract

Eleven trifluoromethylated amines were synthesised in high yield (up to 98%) under metal-free and oxidant-free conditions using iminium salts as starting material and the addition of trifluoromethyltrimethylsilane in dimethylformide containing potassium fluoride.

Publisher

SAGE Publications

Subject

General Chemistry

Reference24 articles.

1. Carbon Trifluoromethylation Reactions of Hydrocarbon Derivatives and Heteroarenes

2. Chiral Drugs

3. YamazakiT., TagauchiT., OjimaI., Fluorine in medicinal chemistry and chemical biology, ed. OjimaI. Wiley-Blackwell, Chichester, 2009, pp. 3–46.

4. The Many Roles for Fluorine in Medicinal Chemistry

Cited by 2 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Making Full Use of TMSCF3: Deoxygenative Trifluoromethylation/Silylation of Amides;Journal of the American Chemical Society;2024-07-03

2. Acute hepatic porphyrias: Current diagnosis & management;Molecular Genetics and Metabolism;2019-11

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3