Heterogeneous Copper-Catalysed Cascade Reactions of 2-Bromobenzamides with β-Keto Esters Leading to Isoquinolin-1(2H)-One Derivatives

Abstract

The heterogeneous copper-catalysed cascade reaction of 2-bromobenzamides with β-keto esters was achieved in dioxane at 80 °C in the presence of the MCM-41-immobilised bidentate nitrogen copper(I) complex [MCM-41-2N-CuI] with Cs2CO3 as base, affording a variety of isoquinolin-1(2 H)-one derivatives in moderate to good yields. This heterogeneous copper catalyst can be recovered by a simple filtration and reused 10 times without significant loss of activity.