Water-Soluble Monochloroplatinum(II) Complexes with Amino Acid Derived Schiff Bases as Ligands: Synthesis, Characterisation and Antitumour Activity

Abstract

A series of water-soluble monochloroplatinum(II) complexes K[PtCl(L)] (L = amino acid derived schiff base) have been synthesised as potential anticancer agents and characterised by 1H NMR, elemental analysis, IR spectroscopy and molar conductivity measurements. These compounds were tested for their DNA interaction ability with salmon sperm DNA and their in vitro anticancer activities have been validated against Hela and A549 cell lines by the CCK-8 assay. Whilst some complexes had better cytotoxic activities against the Hela cell line compared with cisplatin, all the complexes had little cytotoxicity against the A549 cell line compared with cisplatin.