Efficient Oxidative Cyclisation of Acid Hydrazides to 2,5-Disubstituted 1,3,4-Oxadiazoles Catalysed by Bu4NI with t-BuOOH as Oxidant

Abstract

Acid hydrazides or araldehyde N-acylhydrazones can be converted in good yields to, respectively, symmetrical or unsymmetrical, 2,5-disubstituted 1,3,4-oxadiazoles at 60 °C by a Bu4NI-catalysed procedure which requires the presence of a base and 2.5 equiv. of t-butyl hydroperoxide.