Diastereoselective and One-Pot Synthesis of Highly Substituted Cyclohexenones Using Claisen–Schmidt Condensation and Michael Addition-Reference-Cited by-同舟云学术

Diastereoselective and One-Pot Synthesis of Highly Substituted Cyclohexenones Using Claisen–Schmidt Condensation and Michael Addition

Published:2015-09 Issue:9 Volume:39 Page:509-514
ISSN:1747-5198
Container-title:Journal of Chemical Research
language:en
Short-container-title:Journal of Chemical Research

Author:

Mousavi Mir Rasul¹²,Gharari Hadigheh³,Maghsoodlou Malek Taher¹,Hazeri Nourallah¹,Dastorani Parvaneh¹,Soria-Martínez Ruben⁴,García-Granda Santiago⁴

Affiliation:

1. Department of Chemistry, Faculty of Science, University of Sistan and Baluchestan, PO Box 98135-674 Zahedan, Iran

2. Faculty of Science, Payame Nour University of Khoy, Khoy, Iran

3. Sina 24 hour Clinic, Marand, Iran

4. Department of Physical and Analytical Chemistry, University of Oviedo-CINN, Oviedo, Spain

Abstract

A high efficient and convenient one-pot three-component diastreoselective synthesis of polysubstituted cyclohexenones in excellent yields has been developed through Michael addition and Claisen–Schmidt condensation of aldehydes and acetophenone with 3-oxo-N-phenylbutanamide using piperidine as an effective reagent under mild conditions within sort reaction time without using any previous activation.

Publisher

SAGE Publications

Subject

General Chemistry

Link

http://journals.sagepub.com/doi/pdf/10.3184/174751915X14396601175593

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