Rapid and Efficient Synthesis of a New Series of 2-Aryl-5-Fluoro-6-(4-Phenylpiperazin-1-Yl)-1H-Benzimidazoles Using Microwave Heating-Reference-Cited by-同舟云学术

Rapid and Efficient Synthesis of a New Series of 2-Aryl-5-Fluoro-6-(4-Phenylpiperazin-1-Yl)-1H-Benzimidazoles Using Microwave Heating

Published:2015-04 Issue:4 Volume:39 Page:206-208
ISSN:1747-5198
Container-title:Journal of Chemical Research
language:en
Short-container-title:Journal of Chemical Research

Author:

Menteşe Emre¹,Yılmaz Fatih¹,İslamoğlu Fatih¹,Kahveci Bahittin²

Affiliation:

1. Department of Chemistry, Art and Science Faculty, Recep Tayyip Erdogan University 53100-Rize, Turkey

2. Department of Nutrition and Dietetics, Faculty of Health Sciences, Karadeniz Technical University, 61080-Trabzon, Turkey

Abstract

A new series of 2-aryl-5-fluoro-6-(4-phenylpiperazin-1-yl)-1H-benzimidazoles was synthesised from the reaction of 4-fluoro-5-(4-phenylpiperazin-1-yl)benzene-1,2-diamine and iminoester hydrochlorides. 4-Fluoro-5-(4-phenylpiperazin-1-yl)benzene-1,2-diamine was prepared from the reduction of 5-fluoro-2-nitro-4-(4-phenylpiperazin-1-yl)aniline by using Pd/C (10%) catalyst and hydrazine hydrate under microwave irradiation. The structures of newly synthesised compounds were identified by 1H NMR, 13C NMR, mass spectroscopy and elemental analysis data.

Publisher

SAGE Publications

Subject

General Chemistry

Link

http://journals.sagepub.com/doi/pdf/10.3184/174751915X14268750943001

Reference28 articles.

1. The reactions of 3-ethoxycarbonylmethylene-3,4-dihydroquinoxalin-2(1H)-one and its derivatives in the synthesis of benzodiazepines and benzimidazoles: reinvestigation, structural reassignment, and new insight

2. Study of photophysical properties of a series of polymethine dyes by femtosecond laser photolysis

3. Metal-free cross-dehydrogenative coupling of benzimidazoles with aldehydes to N-acylbenzimidazoles

4. The reactions of 3-ethoxycarbonylmethylene-3,4-dihydroquinoxalin-2(1H)-one and its derivatives in the synthesis of benzodiazepines and benzimidazoles: reinvestigation, structural reassignment, and new insight

Cited by 7 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Synthesis of new 1,2-disubstituted benzimidazole analogs as potent inhibitors of β-Glucuronidase and in silico study;Arabian Journal of Chemistry;2022-01

2. Microwave-assisted synthesis of fluoroorganics;Green Sustainable Process for Chemical and Environmental Engineering and Science;2021

3. Synthesis, α-glucosidase inhibition and in silico studies of some 4-(5-fluoro-2-substituted-1H-benzimidazol-6-yl)morpholine derivatives;Bioorganic Chemistry;2020-08

4. Synthesis, molecular docking and biological evaluation of some benzimidazole derivatives as potent pancreatic lipase inhibitors;Bioorganic Chemistry;2018-02

5. Microwave-assisted synthesis of some nitro-benzimidazoles and their salicyl and isatin Schiff bases;Bulletin of the Chemical Society of Ethiopia;2017-11-21