Efficient α-chlorination of 2-[(1-oxocyclohex-2-en-2-yl)methyl]-1,3-dicarbonyl Compounds Using Sodium Hypochlorite-Reference-Cited by-同舟云学术

Efficient α-chlorination of 2-[(1-oxocyclohex-2-en-2-yl)methyl]-1,3-dicarbonyl Compounds Using Sodium Hypochlorite

Published:2013-02 Issue:2 Volume:37 Page:122-124
ISSN:1747-5198
Container-title:Journal of Chemical Research
language:en
Short-container-title:Journal of Chemical Research

Author:

Mhasni Olfa¹,Rezgui Farhat¹

Affiliation:

1. Laboratoire de Chimie Organique, Faculté des Sciences Campus Universitaire 2092 Tunis, Tunisia

Abstract

A rapid and efficient regioselective α-chlorination of a new series of β-dicarbonyl compounds using a commercial solution of sodium hypochlorite in the presence of K2CO3 in THF at 0 °C, is reported. With prolonged reaction times, α-chloro β-keto esters, bearing an acyl moiety, undergo a tandem chlorination–deacylation reaction, affording the corresponding α-chlorinated esters.

Publisher

SAGE Publications

Subject

General Chemistry

Link

http://journals.sagepub.com/doi/pdf/10.3184/174751913X13587668947648

Reference36 articles.

1. Molecular Design, Synthesis, and Hypoglycemic Activity of a Series of Thiazolidine-2,4-diones

2. One-pot synthesis of 2-aminothiazoles using supported reagents

3. Facile Access to N-Thiazolyl α-Amino Acids from α-Bromo Ketones and α-Amino Acids

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