Practical and Efficient Utilisation of (R)-3-chloro-1,2-Propanediol in Synthesis of L-Carnitine-Reference-Cited by-同舟云学术

Practical and Efficient Utilisation of (R)-3-chloro-1,2-Propanediol in Synthesis of L-Carnitine

Published:2011-06 Issue:6 Volume:35 Page:371-372
ISSN:1747-5198
Container-title:Journal of Chemical Research
language:en
Short-container-title:Journal of Chemical Research

Author:

Yang Yunxu¹,Wang Weili¹,Wumaier Aikeremu¹,Sheng Ruilong²,Zhang Xuetao¹,Zhang Tianyi¹

Affiliation:

1. Department of Chemistry and Chemical Engineering, University of Science and Technology Beijing, 100083, P. R. China

2. Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, P. R. China

Abstract

As a by-product originating from Salen Co(III) catalysed hydrolytic kinetic resolution (HKR) of (±)-epichlorohydrin in the manufacturing procedure of L-Carnitine, ( R)-3-chloro-1,2-propanediol was utilised as a starting chiral material to prepare via key nitrile intermediates and by a final hydrolysis L-Carnitine. The new synthetic approach demonstrated an efficient utilisation of the by-product.

Publisher

SAGE Publications

Subject

General Chemistry

Link

http://journals.sagepub.com/doi/pdf/10.3184/174751911X13090786031880

Reference32 articles.

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4. Synthesis of (R)- and (S)-Allyloxiranes via Enantioselective Allylboration of Bromoacetaldehyde. Transformation of (R)-Allyloxirane into (–)-(R)-GABOB (GABOB = γ-amino-β-hydroxybutyric acid)

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