1-[4-(1H-Imidazol-1-yl)Phenyl]-3-Phenylprop-2-En-1-Ones – a Potential Pharmacophore Bearing Anti-Leishmanial Activity-Reference-Cited by-同舟云学术

1-[4-(1H-Imidazol-1-yl)Phenyl]-3-Phenylprop-2-En-1-Ones – a Potential Pharmacophore Bearing Anti-Leishmanial Activity

Published:2016-04 Issue:4 Volume:40 Page:199-204
ISSN:1747-5198
Container-title:Journal of Chemical Research
language:en
Short-container-title:Journal of Chemical Research

Author:

Hussain Tanvir¹,Zia-ur-Rehman Muhammad²,Zaheer Muhammad²,Ashraf Chouhdary Muhammad²,Bolte Michael³

Affiliation:

1. Institute of Chemistry, University of the Punjab, Lahore-54590, Pakistan

2. PCSIR Laboratories Complex, Ferozpur Road, Lahore-54600, Pakistan

3. Institut für Anorganische Chemie, J. W. Goethe-Universität Frankfurt, Max-von-Laue-Str. 7, 60438-Frankfurt/Main, Germany

Abstract

A series of new potentially anti-microbial 1-[4-(1 H-imidazol-1-yl)phenyl]-3-phenylprop-2-en-1-ones was synthesised by condensation of various substituted benzaldehydes with 1-[4-(1 H-imidazol-1-yl)phenyl]ethanone, which was itself prepared by N-arylation of imidazole with p-haloacetophenones, using copper iodide and 1,3-di(pyridin-2-yl)propane-1,3-dione as a catalyst. All the synthesised compounds were subjected to preliminary evaluation for their anti-leishmanial and anti-fungal activities. Some of the synthesised compounds showed significant activities.

Publisher

SAGE Publications

Subject

General Chemistry

Link

http://journals.sagepub.com/doi/pdf/10.3184/174751916X14569208466251

Reference26 articles.

1. Effect of zinc ion on the inhibition of carboxypeptidase A by imidazole-bearing substrate analogues

2. Biological activities of the natural imidazole-containing peptidomimetics n-acetylcarnosine, carcinine and l-carnosine in ophthalmic and skin care products

3. Synthesis, antimicrobial and antiviral evaluation of substituted imidazole derivatives

4. Design, synthesis, and in vitro antitumor activity of new 1,4-diarylimidazole-2-ones and their 2-thione analogues

5. Anti-Plasmodium activity of imidazole–dioxolane compounds

Cited by 4 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. N ‐Arylation of Imidazoles: An Overview;ChemistrySelect;2021-10

2. (E)-3-[4-(1H-Imidazol-1-yl)phenyl]-1-(4-methylphenyl)prop-2-en-1-one;Molbank;2021-08-10

3. (E)-3-(4-Chlorophenyl)-1-(2-fluoro-4-methoxyphenyl)-2-propen-1-one;Molbank;2021-01-25

4. Imidazole bearing chalcones as a new class of monoamine oxidase inhibitors;Biomedicine & Pharmacotherapy;2018-10