Synthesis of Novel Heterocycle Systems: 6,8-Dimethyl-2-(Methylsulfanyl)-4-Amino-Substituted Pyrimido[4′,5′:3,4]Pyrazolo[1,5-a]Pyrimidine and 9,11-Dimethyl-5-(Methylsulfanyl)Pyrimido[2′,1′:5,1]Pyrazolo[4,3-e][1,2,4] Triazolo[4,3-c]Pyrimidine-Reference-Cited by-同舟云学术

Synthesis of Novel Heterocycle Systems: 6,8-Dimethyl-2-(Methylsulfanyl)-4-Amino-Substituted Pyrimido[4′,5′:3,4]Pyrazolo[1,5-a]Pyrimidine and 9,11-Dimethyl-5-(Methylsulfanyl)Pyrimido[2′,1′:5,1]Pyrazolo[4,3-e][1,2,4] Triazolo[4,3-c]Pyrimidine

Published:2014-11 Issue:11 Volume:38 Page:643-647
ISSN:1747-5198
Container-title:Journal of Chemical Research
language:en
Short-container-title:Journal of Chemical Research

Author:

Hasanpour Maede¹²,Eshghi Hossein¹,Bakavoli Mehdi¹,Yusefi Mozhdeh¹

Affiliation:

1. Department of Chemistry, School of Sciences, Ferdowsi University of Mashhad, Mashhad 91775-1436, Iran

2. Department of Chemistry, Payame Noor University (PNU), Iran

Abstract

The novel heterocyclic pyrimidopyrazolopyrimidine system was synthesised through cyclisation of 4-hydrazinyl-2,6-bis(methylthio)pyrimidine-5-carbonitrile with acetylacetone in high yield. Also, two other tetracyclic systems were synthesised through cyclisation of 4-hydrazinyl-6,8-dimethyl-2-(methylsulfanyl)pyrimido[4′,5′:3,4]pyrazolo[1,5- a]pyrimidine with triethyl orthoformate and sodium nitrite to obtain the pyrimidopyrazolotriazolo pyrimidine and pyrimidopyrazolotetrazolopyrimidine respectively.

Publisher

SAGE Publications

Subject

General Chemistry

Link

http://journals.sagepub.com/doi/pdf/10.3184/174751914X14117992793459

Reference17 articles.

1. Synthesis and biological activity of some 4-substituted 1-[1-(2,3-dihydroxy-1-propoxy)methyl-1,2,3-triazol-(4 & 5)-ylmethyl]-1H-pyrazolo[3,4-d]pyrimidines

2. Synthesis and Antimicrobial Activity of Some New Pyrazoles, Fused Pyrazolo[3,4-d]-pyrimidine and 1,2-Dihydroimidazo-[2,1-c][1,2,4]triazin-6-one Derivatives

3. 6-Dimethylamino 1H-Pyrazolo[3,4-d]pyrimidine derivatives as new inhibitors of inflammatory mediators in intact cells

4. Structural modifications and antimicrobial activity of N-cycloalkenyl-2-acylalkylidene-2,3-dihydro-1,3-benzothiazoles

5. Enaminonitrile in heterocyclic synthesis: Synthesis and antimicrobial evaluation of some new pyrazole, isoxazole and pyrimidine derivatives incorporating a benzothiazole moiety

Cited by 3 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Recent advances in the chemistry of pyrazolo[1,5-a]pyrimidines;Advances in Heterocyclic Chemistry;2023

2. Three Heterocyclic Rings Fused (6-5-6);Comprehensive Heterocyclic Chemistry IV;2022

3. ChemInform Abstract: Synthesis of Novel Heterocycle Systems: 6,8-Dimethyl-2-(methylsulfanyl)-4-amino-substituted Pyrimido[4′,5′:3,4]pyrazolo[1,5-a]pyrimidine and 9,11-Dimethyl-5-(methylsulfanyl)pyrimido[2′,1′:5,1]pyrazolo[4,3-e] [1,2,4]triazolo[4,3-c]pyri;ChemInform;2015-05-22