Affiliation:
1. Department of Chemistry, Sarvestan Branch, Islamic Azad University, Sarvestan, Iran
Abstract
A novel three-component condensation reaction between an isocyanide, isoquinoline and thiohydantoins efficiently generates 1,2-dihydroisoquinoline derivatives in a one-pot reaction in water at 70 °C without using any catalyst. Thiohydantoins and isoquinolines exhibit important medicinal properties.
Cited by
5 articles.
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1. Synthesis and dynamic NMR studies of novel hydantoin and thiohydantoin derivatives. Crystal structure of diethyl 2-(4,4-diaryl-2,5-dioxoimidazolidin-1-yl) fumarate and diethyl 2-(4,4-diaryl-2-mercapto-5-oxo-4,5-dihydro-1H-imidazol-1-yl)fumarate;Journal of Chemical Research;2017-05
2. Solvent-free, mild, facile, and rapid one-pot three-component synthesis of some novel imidazo[2,1-b]naphtho[1,2-e][1,3] thiazin-10-ones usingp-TSA;Journal of Sulfur Chemistry;2014-02-11
3. Reaction of alkyl isocyanides and dialkyl acetylenedicarboxylates in the presence of 5,5-diaryl thiohydantoins. Synthesis of functionalized imidazo[2,1-b][1,3]thiazines;Journal of Sulfur Chemistry;2014-01-27
4. Et3N-Mediated Synthesis of N-Vinylthiohydantoins from 5,5-Diarylthiohydantoins and Acetylenic Esters;Journal of Chemical Research;2013-07
5. ChemInform Abstract: A Novel Chemoselective Synthesis of 1,2-Dihydroisoquinolines Linked to 2-Thiohydantoins in Water;ChemInform;2012-10-11