Synthesis of New Pyrazolines and their Biological Evaluation as Antimicrobial Agents-Reference-Cited by-同舟云学术

Synthesis of New Pyrazolines and their Biological Evaluation as Antimicrobial Agents

Published:2012-10 Issue:10 Volume:36 Page:563-565
ISSN:1747-5198
Container-title:Journal of Chemical Research
language:en
Short-container-title:Journal of Chemical Research

Author:

Hamadi Naoufel Ben¹,Haouas Amel¹,Methamem Mahbouba¹,Msaddek Moncef¹

Affiliation:

1. Laboratory of Synthesis heterocyclic and Natural Substances. Department of Chemistry, Faculty of Sciences of Monastir, Boulevard of Environment, 5000 Monastir, Tunisia

Abstract

2-Diazopropane and diazo compounds derived from aromatic aldehydes were reacted with aromatic esters of 3-hydroxyprop-1-yne to give the aromatic esters of 5-hydroxymethyl-3-substituted pyrazoles. Anti-microbial screening using the Gram positive ( Staphylococcus aureus and Enterococcus fecalis) and Gram negative ( Escherichia coli and Klebsiella pneumoniae) bacteria and the yeast Candida albicans, showed that these compounds had promising activity against both Gram positive and Gram negative bacteria.

Publisher

SAGE Publications

Subject

General Chemistry

Link

http://journals.sagepub.com/doi/pdf/10.3184/174751912X13445835381909

Reference18 articles.

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3. A facile and efficient ultrasound-assisted stereospecific synthesis of novel bicyclo-cyclopropanes

4. Synthesis and chemistry of new spiro-Δ1-pyrazoline

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