Iodine-Promoted Synthesis of 3-Arylindolizine-1-Carboxylates from 2-(2-Nitro-1-Arylethyl)Malonates and Pyridine-Reference-Cited by-同舟云学术

Iodine-Promoted Synthesis of 3-Arylindolizine-1-Carboxylates from 2-(2-Nitro-1-Arylethyl)Malonates and Pyridine

Published:2013-09 Issue:9 Volume:37 Page:526-530
ISSN:1747-5198
Container-title:Journal of Chemical Research
language:en
Short-container-title:Journal of Chemical Research

Author:

Li Yun¹,Zhou Zhengquan¹,Ye Weijian¹,Liu Juanjuan¹,Yao Juan¹,Wang Cunde¹

Affiliation:

1. School of Chemistry and Chemical Engineering, Yangzhou University, 180 Siwangting Street, Yangzhou 225002, P. R. China

Abstract

An efficient and straightforward one-pot synthetic protocol has been developed for the synthesis of 3-arylindolizine-1-carboxylates via 1,3-dipolar annulation of 2-(2-nitro-1-arylethyl)malonates with pyridine and subsequent aromatisation in the presence of molecular iodine. The structure of methyl 3-(4-methoxyphenyl)indolizine-1-carboxylate (2a) and methyl 3-iodo-2-(4-nitrophenyl)indolizine-1-carboxylate (2f) was further confirmed by X-ray single crystal analysis.

Publisher

SAGE Publications

Subject

General Chemistry

Link

http://journals.sagepub.com/doi/pdf/10.3184/174751913X13737205567934

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