Synthesis and biological evaluation of novel C1-glycosyl thiazole derivatives as acetylcholinesterase inhibitors-Reference-Cited by-同舟云学术

Synthesis and biological evaluation of novel C1-glycosyl thiazole derivatives as acetylcholinesterase inhibitors

Published:2016-09 Issue:9 Volume:40 Page:545-548
ISSN:1747-5198
Container-title:Journal of Chemical Research
language:en
Short-container-title:Journal of Chemical Research

Author:

Yin Long¹,Cheng Feng–Chang²,Li Qu–Xiang²,Liu Wei–Wei¹³⁴,Liu Xiu–Jian¹,Cao Zhi–Ling¹³,Shi Da–Hua¹³

Affiliation:

1. College of Pharmaceutical Sciences, Huaihai Institute of Technology, Lianyungang 222005, P.R. China

2. China University of Mining and Technology, Xuzhou 221116, P.R. China

3. Jiangsu Institute of Marine Resources, Lianyungang 222005, P.R. China

4. Jiangsu Key Laboratory of Marine Pharmaceutical Compound Screening, Huaihai Institute of Technology, Lianyungang 222005, P.R. China

Abstract

A new series of C1-glycosyl thiazole derivatives was synthesised by the reaction of 1-(1,3,4,6-tetra- O-acetyl-2-deoxy-β-D-glucopyranos-2-yl)thiourea with 2-bromoacetophenone derivatives. Subsequent removal of the acetyl groups were conducted using NaOMe–MeOH. The structures of all new products were confirmed by IR, 1H NMR and HRMS (ESI). The acetylcholinesterase inhibitory activities of these new compounds were tested. Among them, N-(2-acetamido-3,4,6-tri- O-acetyl-2-deoxy-β-D-glucopyranosyl)-4-(4-nitrophenyl)-1,3-thiazole-2-amine showed the best activity with an inhibition rate of 43.21%.

Publisher

SAGE Publications

Subject

General Chemistry

Link

http://journals.sagepub.com/doi/pdf/10.3184/174751916X14711768865726

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