Synthesis and Antibacterial Activities of Pleuromutilin Derivatives with Thiazole-5-Carboxamide and Thioether Moiety-Reference-Cited by-同舟云学术

Synthesis and Antibacterial Activities of Pleuromutilin Derivatives with Thiazole-5-Carboxamide and Thioether Moiety

Published:2011-05 Issue:5 Volume:35 Page:313-316
ISSN:1747-5198
Container-title:Journal of Chemical Research
language:en
Short-container-title:Journal of Chemical Research

Author:

Wang Liang¹,Dai Fu-ying²,Zhu Jie²,Dong Kui-kui¹,Wang Yu-liang¹,Chen Tian²

Affiliation:

1. Faculty of Chemistry, Sichuan University, Chengdu 610065, P. R. China

2. Department of Pathogenic Biology, Chengdu Medical College, Chengdu 610083, P. R. China

Abstract

Seven novel pleuromutilin derivatives with thiazole-5-carboxamide and thioether moiety in the C14 side chain were designed and synthesised. The antibacterial activities of the target compounds were tested via agar-well diffusion method in vitro. The results showed that three target compounds still had antibacterial activity against Staphylococcus aureus ATCC26112 and Staphylococcus aureus SC at a low concentration of 0.05 μg mL−1.

Publisher

SAGE Publications

Subject

General Chemistry

Link

http://journals.sagepub.com/doi/pdf/10.3184/174751911X13057375208346

Reference20 articles.

1. Antibiotic Substances From Basidiomycetes: VIII. Pleurotus Multilus (Fr.) Sacc. and Pleurotus Passeckerianus Pilat

2. (+)-Pleuromutilin synthetic studies. Degradative and de novo acquisition of a levorotatory tricyclic lactone subunit

3. Inhibition of peptide bond formation by pleuromutilins: the structure of the 50S ribosomal subunit from Deinococcus radiodurans in complex with tiamulin

4. CHEMICAL STUDIES WITH PLEUROMUTILIN

5. The Mode of Action of Pleuromutilin Derivatives. Location and Properties of the Pleuromutilin Binding Site on Escherichia coli Ribosomes

Cited by 8 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Potential Nitrogen-Based Heterocyclic Compounds for Treating Infectious Diseases: A Literature Review;Antibiotics;2022-12-03

2. 1,2,4-Oxadiazole-Based Bio-Isosteres of Benzamides: Synthesis, Biological Activity and Toxicity to Zebrafish Embryo;International Journal of Molecular Sciences;2021-02-27

3. Synthesis and Biological Activity of Benzamides Substituted with Pyridine-Linked 1,2,4-Oxadiazole;Molecules;2020-07-31

4. Metal-Free C-H Thiomethylation of Quinones Using Iodine and DMSO and Study of Antibacterial Activity;ChemistrySelect;2019-02-25

5. Amidation of Acid Chlorides to Primary Amides with Ammonium Salts;Chinese Journal of Organic Chemistry;2018