A Facile One-Pot Stereoselective Synthesis of (Z)-α-Acyl-α,α-Unsaturated Esters from Alkynyl Esters and Aryl Acyl Chlorides

Abstract

( Z)-α-Acyl-α,β-unsaturated esters can be stereoselectively synthesised in one pot under mild conditions and in good yields by the palladium-catalysed hydrostannylation of alkynyl esters in benzene, followed by the Stille cross-coupling with aryl acyl chlorides using CuI as co-catalyst.