A Facile One-Pot Synthesis of Novel 1,2,4-Triazolo[4,3-a]Pyridine Derivatives Containing the Trifluoromethyl Moiety Using Microwave Irradiation-Reference-Cited by-同舟云学术

A Facile One-Pot Synthesis of Novel 1,2,4-Triazolo[4,3-a]Pyridine Derivatives Containing the Trifluoromethyl Moiety Using Microwave Irradiation

Published:2015-09 Issue:9 Volume:39 Page:521-523
ISSN:1747-5198
Container-title:Journal of Chemical Research
language:en
Short-container-title:Journal of Chemical Research

Author:

Yang Ming-Yan¹,Zhai Zhi-Wen¹,Sun Zhao-Hui¹,Yu Shu-Jing²,Liu Xing-Hai¹,Weng Jian-Quan¹,Tan Cheng-Xia¹,Zhao Wei-Guang²

Affiliation:

1. College of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310014, P.R. China

2. Collaborative Innovation Center of Chemical Science and Engineering, State Key Laboratory of Elemento-Organic Chemistry, National Pesticide Engineering Research Center, Nankai University, Tianjin 300071, P.R. China

Abstract

A series of novel substituted 8-chloro-6-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyridines are synthesised from 2,3-dichloro-5-(trifluoromethyl)pyridine, hydrazine hydrate as starting materials by multi-step reactions under microwave irradiation. Their chemical structures can be characterised by 1H NMR, MS and elemental analysis. The title compounds exhibit weak antifungal activity.

Publisher

SAGE Publications

Subject

General Chemistry

Link

http://journals.sagepub.com/doi/pdf/10.3184/174751915X14400874295745

Reference18 articles.

1. Microwave Assistant Synthesis, Antifungal Activity and DFT Theoretical Study of Some Novel 1,2,4-Triazole Derivatives Containing Pyridine Moiety

2. Reactions of 2-aminothiphenols with chalcones in an ionic liquid medium: a chemoselective catalyst-free synthesis of 1,5-benzothiazepines

3. Synthesis of various heterocyclic compounds via multi-component reactions in water

4. Synthesis of Unsymmetrical Ureas andS-Thiocarbamates under Catalyst-free Conditions in a [BMIM]BF4Ionic Liquid

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