Catalyst-free synthesis of (7E)-7-benzylidene-3,3a,4,5,6,7-hexahydro-2,3-diphenyl-2H-indazole derivatives in PEG-400 as a green and reusable solvent-Reference-Cited by-同舟云学术

Catalyst-free synthesis of (7E)-7-benzylidene-3,3a,4,5,6,7-hexahydro-2,3-diphenyl-2H-indazole derivatives in PEG-400 as a green and reusable solvent

Published:2016-09 Issue:9 Volume:40 Page:535-539
ISSN:1747-5198
Container-title:Journal of Chemical Research
language:en
Short-container-title:Journal of Chemical Research

Author:

Amoozadeh Ali¹,Tabrizian Elham¹,Salehi Mehdi¹,Kubicki Maciej²,Rahmani Salman¹,Shamsi Taiebeh¹,Bitaraf Mehrnoosh¹

Affiliation:

1. Department of Organic Chemistry, Faculty of Chemistry, Semnan University, Semnan 35131-19111, Iran

2. Faculty of Chemistry, Adam Mickiewicz University, Umultowska 89b, 61-614 Poznan, Poland

Abstract

The reaction of 2,6-bisbenzylidenecyclohexanones and phenylhydrazine in polyethylene glycol (PEG)-400 as a green and reusable solvent under catalyst-free conditions gave hexahydroindazoles as the major product and, in some cases, tetrahydroindazoles were also produced as a minor product. The products were easily separated by simple recrystallisation. The structures of the indazoles were confirmed using FTIR and NMR spectroscopy. Two X-ray structures are reported.

Publisher

SAGE Publications

Subject

General Chemistry

Link

http://journals.sagepub.com/doi/pdf/10.3184/174751916X14709222930154

Reference35 articles.

1. Novel 3, 3a, 4, 5, 6, 7-Hexahydroindazole and Arylthiazolylpyrazoline derivatives as Anti-inflammatory Agents

2. Synthesis and Antitumor Activity of Some Substituted Indazole Derivatives

3. Synthesis and evaluation of DPPH and anti-inflammatory activities of 2,6-bisbenzylidenecyclohexanone and pyrazoline derivatives

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